cyclin d1 gene การใช้

• Chromosomal translocation around the cyclin D1 gene locus is often seen in B mantle cell lymphoma.
• Chromosomal translocation of the cyclin D1 gene locus is also observed in 15  20 % of multiple myelomas.
• Supporting this hypothesis, transcripts originating from enhancers upstream of the Cyclin D1 gene are thought to serve as adaptors for the recruitment of histone acetyltransferases.
• But he cautioned that even though the mice lacking cyclin D1 were largely healthy, that doesn't mean it would be safe to give breast cancer patients a drug that would turn off the cyclin D1 gene in all cells.
• Drugs might be developed to safely silence the cyclin D1 gene, perhaps halting the development of breast tumors without harming normal cells, said the researchers in the laboratory of Robert Weinberg at the Whitehead Institute for Biomedical Research in Cambridge, Mass.